Home  >  Products  >  CA125 Cancer Antigen (Mucin 16, MUC16, MUC-16, CA125, CA-125, Cancer Antigen 125, FLJ14303, Mucin 16 Cell Surface Associated, Cancer-related Tumor Marker CA125, Ovarian Carcinoma Antigen CA125)
CA125 Cancer Antigen (Mucin 16, MUC16, MUC-16, CA125, CA-125, Cancer Antigen 125, FLJ14303, Mucin 16 Cell Surface Associated, Cancer-related Tumor Marker CA125, Ovarian Carcinoma Antigen CA125)

CA125 Cancer Antigen (Mucin 16, MUC16, MUC-16, CA125, CA-125, Cancer Antigen 125, FLJ14303, Mucin 16 Cell Surface Associated, Cancer-related Tumor Marker CA125, Ovarian Carcinoma Antigen CA125)

Cat no: C0050-01D

Supplier: United States Biological
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CA125/MUC16 is a serum marker that is used routinely in gynecologic practice to monitor patients with ovarian cancer. It is a mullerian duct differentiation antigen that is over expressed in epithelial ovarian cancer cells and secreted into the blood, although its expression is not entirely confined to ovarian cancer. Most biochemical studies have concluded that MUC16 is a high molecular mass glycoprotein, although estimates of its size range from 200 to 2000kD with smaller 'subunits' being described by some investigators. Applications: Suitable for use in ELISA, Flow Cytometry, Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilutions: Western Blot: 1-5ug/ml after electrophoresing 20ug of sample. Immunohistochemistry: 1-5ug/ml Note: Dilute in PBS or medium which is identical to that used in the assay system. Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C0050-01D
Reactivities: Human
Hosts: Mouse
Applications: ELISA, Flow Cytometry, Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in 10mM Tris, pH 7.5, 0.15M sodium chloride, 0.05% sodium azide.
P type: Mab
Isotype: IgG1
Purity: Purified by Ion Exchange chromatography.
References: 1. Heinzelmann-Schwarz VA et al. Clin Cancer Res 10:4427-36 (2004).
Additional info: Recognizes human ovarian carcinoma cells. Specifically recognizes epitope specificity group B (ISOBM classification).

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