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CA125 Cancer Antigen (Ovarian Cancer)

CA125 Cancer Antigen (Ovarian Cancer)

Cat no: C2122-08C

Supplier: United States Biological
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MUC16/CA125 antigen is a serum marker that is used routinely in gynecologic practice to monitor patients with ovarian cancer. It is a mullerian duct differentiation antigen that is overexpressed in epithelial ovarian cancer cells and secreted into the blood, although its expression is not entirely confined to ovarian cancer. Most biochemical studies have concluded that MUC16/CA125 is a high molecular mass glycoprotein. According to the ISOBM-TD-1 workshop, CA125 contains three antigenic domains: A-domain (Oc125), B-domain (M11), C-Domain (Ov197). The CA-125 antigen is present on a mucin-like glycoprotein of >200kD and is detectable on the apical surface of normal endometrium and endocervix. CA 125, a high-molecular-weight mucin, was first defined in 1981 by the monoclonal antibody OC125. It is a large glycoprotein which is anchored to the epithelium by a transmembrane domain and is released into the extracellular space by enzymatic cleavage. CA 125 is composed of an N-terminal domain, a tandem repeat region, and a short cytoplasmic tail. The N-terminal domain consists of 1637aa, the tandem repeat domain is made up of 40
Catalogue number: C2122-08C
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry, Immunohistochemistry, Western Blot
Size: 500ul
Form: Supplied as a liquid containing sodium azide
P type: Mab
Isotype: IgG1
Purity: Purified
References: 1. Alagoz et al. Gynacol Oncol 53:93, 1994. 2. Franchi et al. Italian J Gynacol Obstet 5: 149, 1993. 3. Marci et al. Gynacol Obstet Invest 37: 143, 1994. 4. Ohmori et al. Pathol Intl 4: 333, 1994. 5. O' Brien et al. Tumour Biol 23: 154, 2002. 6. O' Brien et al. Tumour Biol 22: 348, 2001. 7. Hovig et al. Tumour Biol 22: 345, 2001.
Additional info: Recognizes human CA125 ovarina cancer antigen

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