Carbohydrate antigen 19-9 (CA 19-9) is a protein that exists on the surface of certain cells and is the most frequently used tumor markers in the clinical setting of cancer. It does not cause cancer; rather, it is a protein that is shed by the tumor cells, making it useful as a tumor marker to follow the course of the cancer. CA 19-9 is elevated in most patients with advanced pancreatic cancer, colorectal cancer, lung cancer, gall bladder cancer, gall stones, pancreatitis, cystic fibrosis, and liver disease. Very small amounts of CA 19-9 may also be found in healthy patients. Besides in patients with Lewis antigen blood group type, CA 19-9 is not elevated even in pancreatic cancers as they have a deficiency of fucosyltransferase needed to synthesize CA 19-9.
Applications:
Suitable for use in Immunohistochemistry. Other applications not tested.
Recommended Dilution:
Immunohistochemistry (formalin fixed paraffin embedded): 1:25-1:50
Immunohistochemistry: Frozen
Optimal dilutions to be determined by the researcher.
Positive Control:
Colon carcinoma
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
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