Home  >  Products  >  CA9 (Carbonic Anhydrase 9, Carbonate Dehydratase IX, Carbonic Anhydrase IX, CA-IX, CAIX, Membrane Antigen MN, P54/58N, Renal Cell Carcinoma-associated Antigen G250, RCC-associated Antigen G250, pMW1, G250, MN)
CA9 (Carbonic Anhydrase 9, Carbonate Dehydratase IX, Carbonic Anhydrase IX, CA-IX, CAIX, Membrane Antigen MN, P54/58N, Renal Cell Carcinoma-associated Antigen G250, RCC-associated Antigen G250, pMW1, G250, MN)

CA9 (Carbonic Anhydrase 9, Carbonate Dehydratase IX, Carbonic Anhydrase IX, CA-IX, CAIX, Membrane Antigen MN, P54/58N, Renal Cell Carcinoma-associated Antigen G250, RCC-associated Antigen G250, pMW1, G250, MN)

Cat no: C1105-80J

Supplier: United States Biological
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Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They play a role in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. Carbonic Anhydrase IX Precursor (CA 9) is a transmembrane protein that is expressed in clear-cell renal cell carcinomas, but is not detected in normal kidney or most other normal tissues. CA9 may be involved in cell proliferation and transformation. CA 9 is also known as, carbonate dehydratase IX, renal cell carcinoma associated antigen G250, and p54/58N. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: ELISA: 1:100-1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C1105-80J
Reactivities: Human
Hosts: Rabbit
Applications: ELISA
Size: 100ug
Form: Supplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by Protein G affinity chromatography.
References: 1. Kim HL, Seligson D, Liu X, Janzen N, Bui MH, Yu H, Shi T, Figlin RA, Horvath S, and Belldegrun AS. 2004. Using protein expressions to predict survival in clear cell renal carcinoma. Clin Cancer Res. 10:5464-71. 2. Grabmaier K, A de Weijert MC, Verhaegh GW, Schalken JA, and Oosterwijk E. 2004. Strict regulation of CAIX(G250/MN) by HIF-1alpha in clear cell renal cell carcinoma. Oncogene. 23:5624-31. 3. Bui MH, Visapaa H, Seligson D, Kim H, Han KR, Huang Y, Horvath S, Stanbridge EJ, Palotie A, Figlin RA, and Belldegrun AS. 2004. Prognostic value of carbonic anhydrase IX and KI67 as predictors of survival for renal clear cell carcinoma. 171:2461-6. 4. Kaluzova,M., Kaluz,S., Lerman,M.I. and Stanbridge,E.J. 2004. DNA damage is a prerequisite for p53-mediated proteasomal degradation of HIF-1alpha in hypoxic cells and downregulation of the hypoxia marker carbonic anhydrase IX. Mol. Cell. Biol. 24:5757-5766. 5. Hedley,D., Pintilie,M., Woo,J., Morrison,A., Birle,D., Fyles,A., Milosevic,M. and Hill,R. 2003. Carbonic anhydrase IX expression, hypoxia, and prognosis in patients with uterine cervical carcinomas. Clin. Cancer Res. 9:5666-5674.
Additional info: Recognizes human Carbonic Anhydrase IX Precursor.

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