Home  >  Products  >  CA9, CT (Carbonic Anhydrase 9, Carbonate Dehydratase IX, Carbonic Anhydrase IX, CA-IX, CAIX, Membrane Antigen MN, P54/58N, Renal Cell Carcinoma-associated Antigen G250, RCC-associated Antigen G250, pMW1, G250, MN)

CA9, CT (Carbonic Anhydrase 9, Carbonate Dehydratase IX, Carbonic Anhydrase IX, CA-IX, CAIX, Membrane Antigen MN, P54/58N, Renal Cell Carcinoma-associated Antigen G250, RCC-associated Antigen G250, pMW1, G250, MN)

Cat no: C1105-80L


Supplier: United States Biological
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Carbonic anhydrases (CA) are a family of ancient zinc metalloenzymes found in almost all living organisms. All CAs can be divided into 3 distinct classes (a, b, and y) that evolved independently and have no significant homology in sequence and overall folding. All functional CAs catalyze the reversible hydration of CO2 into HCO3- and H+ and contain a zinc atom in the active sites essential for catalysis. There are many isoforms of CA in mammals and they all belong to the a class (1,2). CA9 is a member of alpha class, a plasma membrane protein with the catalytic domain in the extracellular space. Its expression is restricted to very few normal tissues (mainly the gastrointestinal tract) (2). CA9 expression is strongly induced by hypoxia and down-regulated by the wildtype von Hippel
Catalogue number: C1105-80L
Reactivities: Human
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ul
Form: Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 100ug/ml BSA, <0.02% sodium azide, 50% glycerol.
P type: Mab
Isotype: IgG
Purity: Supernatant
References: 1.Smith, K.S. et al. (1999) Proc Natl Acad Sci USA 96, 15184-9. 2.Tripp, B.C. et al. (2001) J Biol Chem 276, 48615-8. 3.Potter, C.P. and Harris, A.L. (2003) Br J Cancer 89, 2-7. 4.Winum, J.Y. et al. (2009) Anticancer Agents Med Chem 9, 693-702. 5.De Simone, G. and Supuran, C.T. (2010) Biochim Biophys Acta 1804, 404-9.
Additional info: Recognizes endogenous level of total human CA9.

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