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Cabozantinib L-Malate Salt

Cabozantinib L-Malate Salt

Cat no: 005487

Supplier: United States Biological
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Cabozantinib is a small molecule C-Met modulator. Cabozantinib acts as a potent multitargeted VEGFR2, Met, FLT3, Tie2, Kit and Ret inhibitor with IC50 of 0.035, 1.8, 14.4, 14.3 and 4.6 nM for VEGFR2, Met, FLT3, Tie2 and Kit, respectively. Cabozantinib shows dose-dependent inhibition of tumor growth and tumor regression, associated with disruption of the tumor vasculature and extensive tumor cell apoptosis. Form: Off-White Solid Melting Point: 166-169 degrees C Solubility: DMSO
Catalogue number: 005487
Size: 10mg
Form: Off-White Solid
Alternative names: N-[4-[(6,7-Dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide (2S)-
References: Camp, R., et al.: Cancer, 86, 2259

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