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CACNG1 pAb

CACNG1 pAb

Cat no: BS5785

Supplier: Bioworld Technology, Inc.
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Voltage-dependent calcium channels are essential for the release of neurotransmitters. L-type (long lasting current) voltage-dependent calcium channels are composed of four subunits: an (alpha)1 subunit, a (beta) subunit, a (gamma) subunit and an (alpha)2(delta) subunit. The (beta) subunit is encoded by four genes, designated (beta)1-(beta)4, all of which contribute to the diversity of calcium currents and are involved in membrane trafficking of the (alpha)1 subunit. L-type Ca ++ CP (gamma)1, also known as CACNLG or CACNG1, is a 222 amino acid multi-pass membrane protein belonging to the PMP-22/EMP/MP20 family. Expressed in skeletal muscle, L-type Ca ++ CP (gamma)1 is a subunit of the dihydropyridine (DHP) sensitive calcium channel and may play a role in excitation-contraction coupling. L-type Ca++ CP (gamma)1 is considered a novel marker for malignant hyperthermia susceptibility (MHS), an autosomal dominant disorder of skeletal muscle which manifests as a life-threatening hypermetabolic crisis triggered by commonly used inhalation anaesthetics and depolarizing muscle relaxants.
Catalogue number: BS5785
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Western Blot
Size: 100ug/100ul
Swiss prot: Q06432
Dilutions: WB: 1:500~1:1000
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic peptide, corresponding to the 177-222 of Human CACNG1.
Species: CACNG1 pAb detects endogenous levels of CACNG1 protein.
Molecular weight: ~ 25 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: Voltage-dependent calcium channel gamma-1 subunit; Dihydropyridine-sensitive L-type, skeletal muscle calcium channel subunit gamma; CACNLG; L-type Ca++ CP (gamma)1; L-type Ca++ CP(gamma)1
Additional info: For research use only, not for use in diagnostic procedure.

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