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Cadherin 5 (L-CAM, Epithelial Cell Adhesion Molecule, Vascular Endothelial, VE, CDH5, CD144) (FITC)

Cadherin 5 (L-CAM, Epithelial Cell Adhesion Molecule, Vascular Endothelial, VE, CDH5, CD144) (FITC)

Cat no: C0108-01C

Supplier: United States Biological
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Human vascular endothelium cadherin is an endothelium-specific cadherin localized at the intercellular junctions. Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha catenin forming a link to the cytoskeleton. Applications: Suitable for use in Flow Cytometry, Western Blot, Immunohistochemistry, and Immunoassays. Other applications not tested. Recommended Dilution: Flow Cytometry: 1:10 Western Blot: 1:10 Immunohistochemistry (frozen): 1:10 Optimal dilutions to be determined by the researcher. Storage and Stability: For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. FITC conjugates are sensitive to light.
Catalogue number: C0108-01C
Reactivities: Human
Hosts: Mouse
Applications: Flow Cytometry, Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 1% BSA, 0.02% sodium azide. Labeled with fluorescein isothiocyanate (FITC).
P type: Mab
Isotype: IgG2a
Purity: Purified by Protein G affinity chromatography.
Alternative names: 7B4, Cadherin-5, CD144
References: 1. Navarro, P et al; Catenin-dependent and -independent functions of vascular endothelial cadherin. J Biol Chem 1995, 270: 30965 2. Lampugnani, MG et al; The molecular organization of endothelial cell to cell junctions: differential association of plakoglobin, beta-catenin and alpha-catenin with vascular endothelial cadherin (VE-cadherin). J Cell Biol 1995, 129: 203 3. Martin-Padura, I et al; Expression of VE (vascular endothelial)-cadherin and other endothelial-specific markers in haomangiomas. J path 1995, 175: 51 4. Breviario, F et al; Functional properties of human vascular endothelial cadherin (7B4/Cadherin-5), an endothelium-specific cadherin. Arterioscler Thromb 1995, 15: 1229
Additional info: Recognizes human VE-cadherin.

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