Home  >  Products  >  Cadherin E (Epithelial Cadherin, E-Cadherin, ECAD, CDHE, Arc 1, Arc-1, Cadherin 1, Cadherin-1, CDH1, CAM 120/80, CAM-120/80, CD324, CD324 Antigen, LCAM, Uvomorulin, UVO)
Cadherin E (Epithelial Cadherin, E-Cadherin, ECAD, CDHE, Arc 1, Arc-1, Cadherin 1, Cadherin-1, CDH1, CAM 120/80, CAM-120/80, CD324, CD324 Antigen, LCAM, Uvomorulin, UVO)

Cadherin E (Epithelial Cadherin, E-Cadherin, ECAD, CDHE, Arc 1, Arc-1, Cadherin 1, Cadherin-1, CDH1, CAM 120/80, CAM-120/80, CD324, CD324 Antigen, LCAM, Uvomorulin, UVO)

Cat no: C0108-25V

Supplier: United States Biological
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One of the epithelial cell adhesion molecules, E-Cadherin, plays an important role in the formation of cell-cell contacts in epithelia irrespective their origin form ecto-, meso- or endodermal tissue. This early adhesion event between epithelial cells is a prerequisite for the assembly of all elements of the junctional complex. Furthermore, E-Cadherin plays a crucial role in the maintenance of the epithelial junctional complex and is as such an important molecule in maintaining epithelial integrity. Over 90% of the malignant tumors are carcinomas. One of the prerequisites for the release of carcinoma cells from the primary site might be a defect in intercellular adhesion mediated by the absence of E-Cadherin expression. Therefore, the expres
Catalogue number: C0108-25V
Hosts: Mouse
Applications: Immunohistochemistry, Western Blot
Size: 1ml
Form: Supplied as a liquid.
P type: Mab
Isotype: IgG1
Purity: Supernatant
Alternative names: Cadherin 1 Type 1 E-cadherin (Epithelial)
References: 1. Frixen,U.H., et al. E Cadherin-mediated Cell Cell Adhesion Prevents Invasiness of Human Carcinoma Cells (1991). The Journal of Cell Biology, 113 2. Umbas R., Schalken J.A., Aalders T.W., Carter B.S., Karthaus H.F.M., Schaafsma H.E., Debruyne F.M.J., Isaacs W.B. Expression of the Cellular Adhesion Molecule E-Cadherin is Reduced or Absent in High Grade Prostate Cancer. Cancer Research (1992), 52, 5401-5109.
Additional info: Recognizes human Uvomorulin.

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