N-cadherin (NCAD) is a member of the cadherin cell-cell adhesion receptor family that includes P-, E-,and R-cadherin and liver cell adhesion molecule (L-CAM). N-Cadherin, also known as Cadherin-2, encodes a 907aa protein that includes a 159aa signal sequence. Human and mouse nucleotide sequences are 96% identical. Mouse Ncad gene consists of 16 exons dispersed over more than 200kb of genomic DNA. Human N-cadherin gene contains 16 exons and its sequence is highly similar to both the mouse NCAD gene (including the large first and second introns) and other cadherin genes. N-cadherin is mapped to 18q11.2. Cadherin regulates dendritic spine morphogenesis.
Applications:
Suitable for use in Western Blot, Immunohistochemistry, and Immunofluorescence. Other applications not tested.
Recommended Dilution:
Western Blot: 2ug/ml
Immunohistochemistry (frozen): 4ug/ml
Optimal dilutions to be determined by the researcher.
Storage and Stability:
May be stored at 4 degrees C for short-term only. For long-term storage, aliquot to avoid repeated freezing and thawing and freeze at -70 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquots are stable for at least 12 months.
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