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Cadherin N (Cadherin-2, CDw325, Neural Cadherin, N-cadherin, CD325, CDH2, CDHN, NCAD)

Cadherin N (Cadherin-2, CDw325, Neural Cadherin, N-cadherin, CD325, CDH2, CDHN, NCAD)

Cat no: C0107-03H

Supplier: United States Biological
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Cadherins are a family of transmembrane glycoproteins responsible for maintaining the integrity of tissue and are involved in cell differentiation, cell migration and intracellular adhesion through a calcium dependent mechanism characterized by homotypic adhesion.Their highly conserved cytoplasmic domains associated with catenins, thus mediating contact between cadherins and the microfilaments of cytoskeleton. Each cadherin subclass, shows a unique tissue distribution with E-cadherin expressed in epithelial cells and P-cadherin restricted to decidua tissue and the basal or lower layers of stratified epithelium. Cadherins are expressed in a tissue specific manner and and are required for assembly of cells into solid tissue. Cadherins play an important part in tumor invasion and metastasis. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (formalin fixed paraffin embedded): 1:25-1:50 (ABC) Optimal dilutions to be determined by the researcher. Positive Control: Tonsil Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C0107-03H
Reactivities: Bovine, Canine, Chicken/Bird, Feline, Goat, Guinea Pig
Hosts: Mouse
Applications: Immunohistochemistry
Size: 500ul
Form: Supplied as a liquid, sodium azide.
P type: Mab
Isotype: IgG1
Purity: Ascites
References: 1. Tepass et al. Nat Rev Mol Cell Biol 1: 91, 2000. 2. Goodsell et al. Oncologist 7: 467, 2002. 3. Wheelock et al. Annu Rev Cell Dev Biol 19: 207, 2003. 4. Geiger et al. J cell Sciences 97: 607, 1990. 5. Grunwald et al. Curr Opin Cell Biol 5: 797, 1993. 6. Takeichi et al. Development 102: 639, 1988. 7. Jianzhou et al. Urological Research 28: 308, 2000.
Additional info: Recognizes chicken Cadherin, pan. Species Crossreactivity: bovine, feline, canine, goat, guinea pig, hamster.

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