Cadherin N, Control Peptide (Cadherin 2, Neuronal, CDH2)

Cadherins are a family of CA2+ dependent intercellular adhesion molecules that play a central role in controlling morphogenetic movements during development. Their function is regulated by association with the actin cytoskeleton by a complex of cytoplasmic proteins called the catenin (alpha, beta and gamma). Members of the cadherin family include Cadherin 6 (K-Cadherin), P-cadherin, E-cadherin (uvomorulin), N-cadherin (neural cadherin), R-Cadherin, cadherin 5, L-CAM and EP-Cadherin.\n\nN-Cadherin mRNA is found at elevated levels in brain and heart and at much lower level in liver. Mechanisms such as mRNA expression, cytokine modulation and protease mediated turnover modulate N-cadherin protein levels during development. In addition, N-cadherin function is indirectly regulated by endogeneous kinases and phosphatases. Tyrosine phosphorylation of Beta-Catenin complexed with N-Cadherin results in dissociation of N-Cadherin from actin. However, N-Cadherin also interacts with a PTP1-B-like phosphatase that dephosphorylates B-catenin and promotes N-Cadherin/actin association. This, N-Cadherin is an integral adhesion molecule whose function is regulated by protein-protein interactions and phosphorylation/dephosphorylation events.\n\nApplications: \nSuitable for use in Western Blotting. Other applications not tested.\n\nStorage and Stability: \nLyophilized powder may be stored at 4 degrees C for short-term only. Stable for 12 months at -20 degrees C. Reconstitute to nominal volume (see reconstitution instructions for peptides) and store at -20 degrees C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.\n\n\n \n

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SPECIFICATIONS

Catalog Number

C0108-35A

Size

1mg

Applications

WB

Reactivities

Mouse, Rat, Ch/Bird

Form

Supplied as a lyophilized powder.

Purity

Purified

References

Packer, A.I. et al. 1997 Int J Dev Biol 41:459-468 \nLee, M.M. et al. 1997 Dev Genet 20:224-234 \nBalsamo J., et al. 1996 J Cell. Biol. 134:801-813

Additional Info

C-terminal region pepide corresponding to aa802-819 of mouse N-cadherin KPVGIRRLDERPIHAEPQ (linear) and used as the control peptide for C0108-35 anti-Cadherin N. Species crossreactivity: Rat, mouse, chicken.