Cadherin N, CT (CDH2, Cadherin 2, type 1, N-cadherin (neuronal), Cadherin-2, Cadherin-2 precursor, CD325, CD325 antigen, CDHN, CDw325, CDw325 antigen, NCAD, N-cadherin, Neural-cadherin, Neural-cadherin precursor)

Cat no: C0107-03C

Supplier: United States Biological

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Cadherins are members of a multigene family of single chain glycoprotein receptors mediating Ca++-dependent cell-cell adhesion.1,2,3 The N-terminal part of these molecules is exposed on the external cell surface and contains the putative homophilic binding sites. This is followed by a typical single transmembrane sequence and usually, a cytoplasmic C-terminal tail4 which mediates interaction with the microfilament system through molecules such as catenins, plakoglobin, vinculin, and a-actinin. Cadherins which are primarily located in areas of cell-cell contacts, are involved in selective cell sorting and in the mechanical cytoplasmic response. They are implicated in morphogenetic processes, intercellular signalling and tumor invasiveness and metastasis. Multiple cadherins were characterized from diverse species and tissues including E-Cadherin, N-Cadherin (A-CAM), P-Cadherin, V-Cadherin, R-Cadherin and T-Cadherin. Specific antibodies against a highly conserved sequence from the cytoplasmic C-terminal of N-Cadherin have been prepared.5,6 Cellular Localization: Cell membrane Applications: Suitable for use in Immunofluorescence, Western Blot and Immunohistochemistry (Fr) (paraffin-embedded sections). Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Catalogue number:	C0107-03C
Reactivities:	Human, Mouse, Rat, Bovine, Canine, Chicken/Bird, Rabbit, Xenopus/Amphibian
Hosts:	Rabbit
Applications:	Immunofluorescence, Immunohistochemistry, Western Blot
Size:	100ul
Form:	Supplied as a liquid (serum) containing sodium azide as preservative.
P type:	Pab
Isotype:	IgG
Purity:	Serum
Alternative names:	NCAD
References:	1. Takeichi, M., Development, 102, 639 (1988). 2. Takeichi, M., Annu. Rev. Biochem., 59, 237 (1990). 3. Takeichi, M., Science, 251, 1451 (1991). 4. Geiger, B., and Ginsberg, D., Cell Mot. Cyto., 20, 1 (1991). 5. Geiger, B., et al., J. Cell Science, 97, 607 (1990) 6. Kartenbeck, K., et al, J. Cell. Biol., 113, 881 (1991).
Additional info:	Recognizes all cadherin members. Rabbit Anti-Pan Cadherin shows specific reactivity with a distinct 135kD band on chicken or rabbit heart extract blots using indirect immunoblotting. This product is useful for the detection of members of the cadherin family or genetically engineered proteins containing the C-terminal cadherin tail, and for demonstration of adherens type cell-cell junctions regardless of their cadherin type. Species Crossreactivity: Crossreacts with Amphibians, Birds, Chicken, bovine, canine, Fish, Human, Mouse, Rabbit, Rat and Xenopus laevis. Not yet tested in other species.

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Cadherin N, CT (CDH2, Cadherin 2, type 1, N-cadherin (neuronal), Cadherin-2, Cadherin-2 precursor, CD325, CD325 antigen, CDHN, CDw325, CDw325 antigen, NCAD, N-cadherin, Neural-cadherin, Neural-cadherin precursor)

Cat no: C0107-03C

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