Cadherin, pan

Cat no: C0107-03B

Supplier: United States Biological

0 reviews | Write a Review Pencil

Read More on Supplier Website

Description
Additional Information

Cadherins are members of a multigene family of single chain glycoprotein receptors mediating Ca2+-dependent cell-cell adhesion(1,2,3). The N-terminal part of these molecules is exposed on the external cell surface and contains the putative homophilic binding sites. This is followed by a typical single transmembrane sequence and usually a cytoplasmic C-terminal tail which mediates interaction with the microfilament system through molecules such as catenins, plakoglobin, vinculin, and alpha-actinin. Applications: Suitable for use in Immunofluorescence, Western Blot, Immunohistochemistry and Immunocytochemistry. Other applications not tested. Recommended Dilutions: Western Blot: 1:1000-1:2000 Immunofluorescence: 1:500-1:1000 on cultured cells using methanol/acetone fixation Immunohistochemistry (Paraffin): 1:500-1:1000 Immunohistochemistry: Frozen Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Catalogue number:	C0107-03B
Reactivities:	Human, Mouse, Rat, Bovine, Canine, Chicken/Bird, Feline, Goat, Guinea Pig, Porcine, Rabbit, Sheep
Hosts:	Mouse
Applications:	Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
Size:	100ul
Form:	Supplied as a liquid, 15mM sodium azide.
P type:	Mab
Isotype:	IgG1
Purity:	Ascites
Alternative names:	NCAD
References:	1. Takeichi, M., Development, 102, 639 (1988). 2. Takeichi, M., Ann. Rev. Biochem., 59, 237 (1990). 2 . Takeichi, M., Science, 251, 1451 (1991). 4. Grunwald, G., Curr. Opin. Cell Biol. 5, 797 (1993). 5. Takeichi, M., Curr. Opin. Cell Biol. 5, 806 (1993). 6. Geiger, B., et al., J. Cell Science, 97, 607 (1990). 7. Kartenbeck, J., et al., J. Cell. Biol., 113, 881 (1991).
Additional info:	Recognizes all cadherins at ~125-140kD; location is tissue dependent. Species Crossreactivity: human, mouse, rat, feline, chicken, bovine, canine, goat, guinea pig, hamster, porcine, psammoys (sand rat), rabbit, sheep and snake.

See Full Product Listings >

Cadherin, pan

Cat no: C0107-03B

Get Quote

About Biosave

Product Categories

Information


Get a Quote Direct from United States Biological




By submitting this form you agree to your details being passed to United States Biological for the purpose of generating the best quote*