Home  >  Products  >  Cadherin T, NT (Truncataed Cadherin, T-Cadherin, T-CAD, Cadherin 13, Cadherin-13, CDH13, CDHH, Heart Cadherin, H-Cadherin, P105)
Cadherin T, NT (Truncataed Cadherin, T-Cadherin, T-CAD, Cadherin 13, Cadherin-13, CDH13, CDHH, Heart Cadherin, H-Cadherin, P105)

Cadherin T, NT (Truncataed Cadherin, T-Cadherin, T-CAD, Cadherin 13, Cadherin-13, CDH13, CDHH, Heart Cadherin, H-Cadherin, P105)

Cat no: C0108-51

Supplier: United States Biological
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T-cadherin was initially identified as cadherin-type cell adhesion molecule expressed in various neuronal populations in a temporally and spatially restricted pattern during axon growth. T-cadherin is an atypical member of the cadherin family because it does not possess the typical transmembrane and cytoplasmic domains but is instead anchored to the plasma membrane by glycosylphosphatidylinositol (GPI) linkage. T-cadherin may play a role in malignant tumor development as loss of the chromosome locus containing the T-cadherin gene correlates with the development of a variety of cancers. Recently it has been shown that T-cadherin can act as a receptor for hexameric and high-molecular weight forms of adiponectin, suggesting that T-cadherin may also play a role in metabolic regulation. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.5-1ug/ml Optimal dilutions to be determined by the researcher. Positive Control: 3T3 cell lysate Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C0108-51
Reactivities: Human, Mouse
Hosts: Rabbit
Applications: Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Ranscht B and Dours-Zimmerman MT. T-cadherin, a novel cadherin cell adhesion molecule in the nervous system lacks the conserved cytoplasmic region. Neuron 1991;7:391-402. 2. Ivanov DB, Philippova MP, and Tkachuk VA. Structure and functions of classical cadherins Biochemistry (Moscow) 2001;66:1175-66. 3. Takeuchi T, Misaki A, Chen BK, et al. H-cadherin expression in breast cancer. Histopathology 1999;35:87-88. 4. Sato M, Mori Y, Sakurada A, et al. The H-cadherin (CDH13) gene is inactivated in human lung cancer. Hum. Gen. 1998;103:96-101. 5. Hug C, Wang J, Ahmad NS, et al. T-cadherin is a receptor for hexameric and high-molecular-weight forms of acrp30/adiponectin. Proc. Natl. Acad. Sci. USA 2004;101:10308-13.
Additional info: Recognizes human T-cadherin (NT). Species Crossreactivity: mouse.

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