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Calciseptine (Recombinant)

Cat no: RTC-500

Calciseptine (Recombinant)

Calciseptine (Recombinant). L-TypeпїЅCavпїЅChannel Blocker.
Natural Calciseptine (Recombinant) is a peptidyl toxinпїЅoriginally isolated from theпїЅDendroaspis p. polylepsisпїЅblack mamba venom. Calciseptine (Recombinant) was shown to be a specific L-type Cavchannel blocker. In contrast, it increases L-type currents in skeletal muscle.
Calciseptine (Recombinant) blocks spontaneous or K+-induced contraction of cardiac and smooth muscle cells. Using patch clamp, it was also shown to block specifically L-type CavпїЅchannel current in neuronal cells in culture. For these variety of effects, theпїЅIC50's were in the range ofпїЅ15-500 nM. Using the outside-out configuration of patch clamp, it was shown to reduce single L-type channels open probability and availability as recorded from Guinea pig portal vein.

Calciseptine (Recombinant) is a recombinant peptide expressed in and extracted from E.пїЅcoli, purified to homogeneity and confirmed by mass spectrometry analysis. The Calciseptine (Recombinant) contains an additional methionine at the N-terminus.
The ability of rCalcoseptine to block L-type Ca2+пїЅcurrent is tested inпїЅXenopusпїЅoocyteпїЅand foundпїЅsimilar to that of natural Calciseptine (Recombinant) (C-500). This proves that this modification does not affect its activity properties.

Alomone Labs is pleased to offer Calciseptine (Recombinant), an economical product at a very attractive price.

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SPECIFICATIONS

Catalog Number

RTC-500

Size

0.1 mg

Purity

>98%

Concentration

100 nM - 2 micro M.

Shipping Temp

Room Temperature

Molecular Weight

7167.4 da

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