HiTSeeker CALCR Assay Cell Line contains HEK293 cells stably expressing human Calcitonin Receptor (CALCR) with no tag. We offer this cell line as a stable cell line but we are now also offering vials of division-arrested cells (DA cells) in order to perform a small number of assays. Each vial of these DA cells contains 2.5 million cells, an enough number of cells to perform a complete experiment in a 96 well-plate or 384 well-plate. Innoprot HiTSeeker CALCR Assay Cell Line has been designed to assay compounds or analyze their capability to modulate Calcitonin receptor. When Calcitonin binds to the CALCR a G protein is activated, which in turn, triggers a cellular response mediated by second messengers (Calcium and cAMP). This cell line has been validated measuring calcium and cAMP increase in the cytosol. The high reproducibility of this assay allows monitoring CALC receptor activation process in High Throughput Screening.
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