Home  >  Products  >  Calcium Sensing Receptor (CASR)
Calcium Sensing Receptor (CASR)

Calcium Sensing Receptor (CASR)

Cat no: C0117-05A

Supplier: United States Biological
Star_fadedStar_fadedStar_fadedStar_fadedStar_faded
0 reviews | Write a Review Pencil
Read More on Supplier Website
The calcium-sensing receptor (CaSR) is an integral membrane protein that is a member of the G protein-coupled receptor family. It senses changes in the extracellular concentration of calcium ions. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. Most cell lines do not express endogenous Ca++ sensing receptor. Studies have been done with HEK-293 or MDCK cells stabily or transiently expressed lysates. This protein is also found in native tissues. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:50-1:200 Recognizes a band at ~130kD and a large smear at the top of the gel. This protein is susceptible to aggregation, thus resulting in just seeing the high MW smear. Optimal dilutions to be determined by the researcher. Positive Control: Human Kidney Protein Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C0117-05A
Reactivities: Human, Mouse, Rat, Rabbit
Hosts: Mouse
Applications: Western Blot
Size: 100ul
Form: Supplied as a liquid in Tris-glycine, 150mM sodium chloride, 0.05% sodium azide.
P type: Mab
Isotype: IgG1,k
Purity: Purified by Protein G affinity chromatography.
Alternative names: Parathyroid Cell Calcium-sensing Receptor
References: 1. Handlogten, M.E., et al. The extracellular Ca-sensing receptor is a promiscuous divalent cation sensor that responds to lead. Am. J. Physiol. (Renal), 279: F1083-F1091, 2000. 2. Awata, H., et al. Interaction of the Calcium-sensing Receptor and Filamin, a Potential Scaffolding Protein. JBC. 276(37): 34871-34879, 2001. [Immunogen] 3. Handlogten, M.E., C. Huang, N. Shiraishi, H. Awata, and R.T. Miller. The Ca receptor activates cPLA2 via a G
Additional info: Recognizes human Calcium Sensing Receptor protein. Species Crossreactivity: mouse, rat, rabbit.

Get Quote

  • Best Price Guaranteed
  • Quick Response Time
  • Exclusive Promotions
Enquiry_down_arrow
United States Biological
Get a Quote Direct from
United States Biological

By submitting this form you agree to your details being passed to United States Biological for the purpose of generating the best quote*
See Full Product Listings >
Button_on Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave