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Calcium Sensing Receptor (CASR)

Calcium Sensing Receptor (CASR)

Cat no: C0117-05B

Supplier: United States Biological
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The calcium sensing receptor (CaSR) has been shown to play a major role in regulating parathyroid hormone secretion and subsequently influencing the calcium concentration of extracellular fluids. Based on sequence analysis of cDNA clones it appears that the CaSR is similar to the 7-transmembrane- domain G-protein-coupled receptor superfamily. Changes in extracellular calcium are thought to modulate a balance between proliferation and differentiation in a variety of cell types. In normal primary keratinocytes and breast epithelial cells, proliferation is inhibited and elevated extracellular calcium levels trigger differentiation. Malignant transformations of these cell types are accompanied by a loss of responsiveness to the anti-proliferative effects of elevated extracellular calcium. Several disorders of calcium homeostasis have been linked to mutations in the CaSR. These include familial hypocalciuric hypercalcemia (FHH), neonatal severe hyperparathyroidism (NSHPT), and autosomal dominant hypocalemia (ADHypo). Applications: Suitable for use in ELISA, Western Blot, Flow Cytometry, Immunofluorescence and Immunohistochemistry. Other applications not tested. Recommended Dilutions: Immunohistochemistry (Frozen): 2ug/ml Immunohistochemistry: 1:10-1:2000 Western Blot: 2ug/ml detects a band at ~130 and 150kD ELISA: 1:100-1:2000 Flow Cytometry: 1:10-1:1000 Immunofluorescence (IC): 1:10-1:2000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C0117-05B
Reactivities: Human, Mouse, Rat, Bovine
Hosts: Mouse
Applications: ELISA, Flow Cytometry, Immunofluorescence, Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 1mg/ml BSA, 0.05% sodium azide.
P type: Mab
Isotype: IgG2a
Purity: Purified
Alternative names: Parathyroid Cell Calcium-sensing Receptor
References: 1.Goldsmith PK et al. Expression, purification, and biochemical characterization of the amino-terminal extracellular domain of the human calcium receptor. J Biol Chem 274:11303-9 (1999). 2. Goldsmith PK et al. Monoclonal antibodies against synthetic peptides corresponding to the extracellular domain of the human Ca2+ receptor: characterization and use in studying concanavalin A inhibition. J Bone Miner Res 12:1780-8 (1997). 3. Garrett JE et al. Molecular cloning and functional expression of human parathyroid calcium receptor cDNAs. J Biol Chem 270:12919-25 (1995).
Additional info: Recognizes human Calcium Sensing Receptor. Species Crossreactivity: rat, mouse and bovine

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