Caldesmon, phosphorylated, Ser789

Cat no: C0132-14Q

Supplier: United States Biological

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Description
Additional Information

Caldesmon is a regulatory protein found in smooth muscle and other tissues which interacts with actin, myosin, tropomyosin, and calmodulin. Caldesmon antibody labels smooth muscle and tumors of smooth muscle, myofibroblastic, and myoepithelial differentiation. Caldesmon has also been used to differentiate epithelioid mesothelioma from serous papillary carcinoma of the ovary. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (Paraffin, frozen): 1:25-1:100 Optimal dilutions to be determined by the researcher. Positive Control: Smooth muscle from various sources including bowel, esophagus, uterus Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Catalogue number:	C0132-14Q
Reactivities:	Human
Hosts:	Rabbit
Applications:	ELISA, Immunohistochemistry
Size:	1ml
Form:	Supplied as a liquid in PBS, pH7.4, protein base, sodium azide.
P type:	Mab
Purity:	Supernatant
References:	1. CominCE,SaievaC,MesseriniL.h-caldesmon,calretinin,estrogenreceptor,andBer-EP4:auseful combination of immunohistochemical markers for differentiating epithelioid peritoneal mesothelioma from serous papillary carcinoma of the ovary. Am J Surg Pathol. 2007 Aug;3198): 1139-48 2. WatanabeK,KusakabeT,HoshiN,SaitoA,SuzukiT.h-Caldesmoninleiomyosarcomaandtumors with smooth muscle cell-like differentiation: its specific expression in the smooth muscle cell tumor. Hum Pathol. 1999 Apr;30(4): 392-6 3. McCluggageWC.Acriticalappraisalofthevalueofimmunohistochemistryindiagnosisofuterine neoplasms. Adv Anat Pathol. 2004 May; 11(3): 162-71 4. MiettinenM.,LasotaJ.Gastrointestinalstromaltumors:reviewonmorphology,molecular pathology, prognosis, differential diagnosis. Arch Pathol Lab Med. 2006 Oct; 130(10): 1466-78 5. Comin CE. et al. h-Caldesmon, a useful positive marker in the diagnosis of pleural mesothelioma, epitheliod type. Am J Surg Pathol. 2006 Apr; 30(4): 463-9
Additional info:	Recognizes human Caldesmon. This antibody is not phospho-specific, however, and will recognize total endogenous protein. Staining pattern: Cytoplasmic.

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Caldesmon, phosphorylated, Ser789

Cat no: C0132-14Q

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