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Calmodulin-Dependent Protein Kinase I (CAMKI, CaM Kinase I)

Calmodulin-Dependent Protein Kinase I (CAMKI, CaM Kinase I)

Cat no: C1035-22

Supplier: United States Biological
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Calcium / calmodulin-dependent kinases (CaMKs) are a subfamily of the serine/threonine protein kinase family that includes CaMKI, CaMKII, and CaMKIV. There have been identified multiple substrates for CaMKI, including synapsin 1, synapsin 2, CREB, and CFTR, and its activation is dependent upon phosphorylation of Thr 177 by CaMK kinase (CaMKK). Studies suggest that CaMKI plays an important role in retinal function and its expression is regulated by light stimulation. Positive Control: AtT20 cell extract. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C1035-22
Reactivities: Human, Rat
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: PBS, 1 mg/ml BSA and 0.05% sodium azide
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: Matsushita M & Nairn AC Characterization of the mechanism of regulation of Ca2+/ calmodulin-dependent protein kinase I by calmodulin and by Ca2+/calmodulin-dependent protein kinase kinase. J Biol Chem 273:21473-81 (1998). Haribabu B et al. Human calcium-calmodulin dependent protein kinase I: cDNA cloning, domain structure and activation by phosphorylation at threonine-177 by calcium-calmodulin dependent protein kinase I kinase. EMBO J 14:3679-86 (1995).
Additional info: Detects CaMKI from rat brain extract. Species Crossreactivity: Crossreacts with Rat. Expected to crossreact with Human due to sequence homology.

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