Calphostin C (Antibiotic UCN-1028 C, UCN 1028 C)

Calphostin C is a perylenequinione isolated from the fungus, Cladosporium cladosporioides. It is a potent and specific inhibitor of protein kinase C with inhibition being light dependent. Also shown to inhibit cell proliferation and induce apoptosis in vitro.\n\nPurity: >95% by HPLC\n\nSolubility: Soluble in ethanol, methanol, DMF or DMSO

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SPECIFICATIONS

Catalog Number

C1035-38

Size

100ug

Purity

: >95% by HPLC\n\n

References

1. Growth inhibition induced by Ro 31-8220 and calphostin C in human glioblastoma cell lines is \nassociated with apoptosis and inhibition of CDC2 kinase. Begemann M. et al. Anticancer Res. 1998, 18, \n3139. \n2. Inhibition of protein kinase C by calphostin C is light-dependent. Bruns R.F. et al. Biochem. Biophys. \nRes. Commun. 1991, 176, 288. \n3. Calphostins (UCN-1028), novel and specific inhibitors of protein kinase C. I. Fermentation, isolation, \nphysico-chemical properties and biological activities. Kobayashi E. et al. J. Antibiot. 1989, 42, 1470. \n4. Calphostins, novel and specific inhibitors of protein kinase C. II. Chemical structures. Kobayashi E. et al. \nJ. Antibiot. 1989, 42, 1475.

Alternative Names

Antibiotic UCN-1028 C, UCN 1028 C