Home  >  Products  >  Calponin (Basic Calponin, Calponin 1, Calponin 1 Basic Smooth Muscle, Calponin H1 Smooth Muscle, Calponin1, Calponins Basic, CNN 1, CNN1, Sm Calp, SMCC)
Calponin (Basic Calponin, Calponin 1, Calponin 1 Basic Smooth Muscle, Calponin H1 Smooth Muscle, Calponin1, Calponins Basic, CNN 1, CNN1, Sm Calp, SMCC)

Calponin (Basic Calponin, Calponin 1, Calponin 1 Basic Smooth Muscle, Calponin H1 Smooth Muscle, Calponin1, Calponins Basic, CNN 1, CNN1, Sm Calp, SMCC)

Cat no: C1035-40C

Supplier: United States Biological
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Calponin is a 34kD polypeptide that interacts with actin, tropomyosin, and calmodulin. It is involved in smooth muscle contraction mechanism and is restricted exclusively to smooth muscle tissue. Anti- calponin has been found to be useful in differentiating benign sclerosing lesions of the breast from carcinoma. Calponin positivity has also been noted in malignant myoepithelioma and pleomorphic adenoma of salivary gland origin, as well as angiomatoid malignant fibrous histiocytoma. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (Paraffin, frozen): 1:50-1:200 Optimal dilutions to be determined by the researcher. Positive Control: Smooth muscle from various sources including bowel, esophagus, uterus Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C1035-40C
Reactivities: Human
Hosts: Rabbit
Applications: ELISA, Immunohistochemistry
Size: 1ml
Form: Supplied as a liquid in PBS, pH7.4, protein base, sodium azide.
P type: Mab
Purity: Supernatant
References: 1. WangNP,WanBCetal.Antibodiestonovelmyoepithelium-associatedproteinsdistinguish benign lesions and carcinoma in situ from invasive carcinoma of the breast. Appl. Immunohistochem 5(3):141-151, 1997 2. NagaoT,SuganoI,IshidaY,etal.Salivaryglandmalignantmyoepithelioma:aclinicopathologic and immunochemical study of ten cases. Cancer 1998 Oct 1:83(7):1292-9 3. SavaraAT,GownAM,ZarboRJ.Immunolocalizationofthreenovelsmoothmuscle-specific proteins in salivary gland pleomorphic adenoma; assessment of the morphogenetic role of myoepithelium. Mod Pathol 1997 Nov; 10(11):1093-1100 4. Fanburg-SmithJC,MeittinenM.Angiomatoid
Additional info: Recognizes human Calponin-1. Staining pattern: Cytoplasmic.

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