Home  >  Products  >  Calponin (Basic Calponin, Calponin 1, Calponin 1 Basic Smooth Muscle, Calponin H1 Smooth Muscle, Calponin1, Calponins Basic, CNN 1, CNN1, Sm Calp, SMCC)
Calponin (Basic Calponin, Calponin 1, Calponin 1 Basic Smooth Muscle, Calponin H1 Smooth Muscle, Calponin1, Calponins Basic, CNN 1, CNN1, Sm Calp, SMCC)

Calponin (Basic Calponin, Calponin 1, Calponin 1 Basic Smooth Muscle, Calponin H1 Smooth Muscle, Calponin1, Calponins Basic, CNN 1, CNN1, Sm Calp, SMCC)

Cat no: C1035-40E

Supplier: United States Biological
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Calponin is a 34kD polypeptide that interacts with actin, tropomyosin, and calmodulin. It is involved in smooth muscle contraction mechanism and is restricted exclusively to smooth muscle tissue. Anticalponin has been found to be useful in differentiating benign sclerosing lesions of the breast from carcinoma. Calponin positivity has also been noted in malignant myoepithelioma and pleomorphic adenoma of salivary gland origin, as well as angiomatoid malignant fibrous histiocytoma. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (Paraffin, frozen): 1:50-1:200 Optimal dilutions to be determined by the researcher. Positive Control: Appendix, Breast, Leiomyoma, Uterus Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C1035-40E
Reactivities: Human
Hosts: Mouse
Applications: ELISA, Immunohistochemistry
Size: 1ml
Form: Supplied as a liquid in PBS, pH 7.4, protein base, sodium azide.
P type: Mab
Purity: Ascites
References: 1. Antibodiestonovelmyoepithelium-associatedproteinsdistinguishbenignlesionsandcarcinoma in situ from invasive carcinoma of the breast. Wang NP, Wan BC et al. Appl. Immunohistochem 5(3):141-151, 1997 2. Salivaryglandmalignantmyoepithelioma:aclinicopathologicandimmunochemicalstudyoften cases. Nagao T, Sugano I, Ishida Y, et al. Cancer 1998 Oct 1:83(7):1292-9 3. Immunolocalizationofthreenovelsmoothmuscle-specificproteinsinsalivaryglandpleomorphic adenoma; assessment of the morphogenetic role of myoepithelium. Savara AT, Gown AM, Zarbo RJ. Mod Pathol 1997 Nov; 10(11):1093-1100 4. Angiomatoid
Additional info: Recognizes human Calponin. Staining pattern: Cytoplasmic.

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