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Calretinin (CR, 29kD Calbindin, CAB29, CAL2, CALB2, Calbindin 2 29kDa, Calbindin-2, Calbindin D29K)

Calretinin (CR, 29kD Calbindin, CAB29, CAL2, CALB2, Calbindin 2 29kDa, Calbindin-2, Calbindin D29K)

Cat no: C1036-03H1

Supplier: United States Biological
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Calretinin (CAB29, calbindin 2) is a calcium binding protein that belongs to calbindin family. It is mainly found in neuronal tissue, high expressed in auditory neurons. It has been implicated in as a calcium buffer, calcium sensor, and as a regulator of apoptosis (1). Calretinin is considered as a specific marker of mesothelllal cells; it is the only marker that has the utility in distinguishing between sarcomatoid mesotheliomas and sarcomatoid renal cell carcinomas (2). It is widely used in the panel of makers for distinguishing mesothlioma from adenocarcinoma. Along with calretinin, the panel includes E-cadherin and cytokeratin 5/6 (3). Applications: Suitable for use in Western Blot and Immunoprecipitation. Other applications not tested. Recommended Dilution: Western Blot: 1:1000-1:5000 Immunoprecipitation: 1:50 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Manufactured incorporating RabMAb(R) technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Catalogue number: C1036-03H1
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunoprecipitation, Western Blot
Size: 100ul
Form: Supplied as a liquid in 50mM Tris-glycine, pH 7.4, 0.15M sodium chloride, 40% glycerol, 0.01% sodium azide, 0.05% BSA.
P type: Mab
Isotype: IgG
Purity: Supernatant
References: 1. Plattelli A et al. J Endocl 29(6):394-396, 2003. 2. Ordonez NG et al. Hum Pathol. 35(6):697-710, 2004. 3. Ordonez NG et al. Hum Pathol. 30(3):313-23. 1999.
Additional info: Recognizes human Calretinin. Species Crossreactivity: Mouse and rat.

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