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CaM Kinase II, alpha (Calcium/calmodulin-dependent Protein Kinase Type II Subunit alpha, CaM Kinase II Subunit alpha, CaMK-II subunit alpha, CAMK2A, CAMKA, KIAA0968)

CaM Kinase II, alpha (Calcium/calmodulin-dependent Protein Kinase Type II Subunit alpha, CaM Kinase II Subunit alpha, CaMK-II subunit alpha, CAMK2A, CAMKA, KIAA0968)

Cat no: C1036-76A

Supplier: United States Biological
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CaMKII, one of the most abundant neuronal protein kinases was first identified in neuronal membrane fractions. CaMKII phosphorylates a broad range of substrates and is expected to have pleiotropic regulatory actions in cellular differentiation and mature neuronal functions. This enzyme is composed of four different chains: alpha, beta, gamma, and delta. The alpha subunit of CaMKII is identified as the major postsynaptic density protein (mPSDp). It undergoes calcium/calmodulin-dependent autophosphorylation on Thr286 in its regulatory domain, rendering the kinase partially calcium-independent. Thus this Thr286 autophosphorylation controls subcellular targeting of CaMKII in neurons with important functional consequences. The protein is enriched in brain and its overexpression alters the general cell growth, differentiation, and morphology of neurons. human CaMKII gene maps on chromosome 5 at 5q33.1. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:500-1:1000 Immunohistochestry (paraffin): 1:50-1:100 Optimal dilutions to be determined by the researcher. Positive Control: Mouse brain tissue Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C1036-76A
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
Alternative names: Calcium/calmodulin-dependent Protein Kinase II alpha, EC=2.7.11.17
References: 1. Thierry, M. et al. The Journal of Neuroscience. 17:924-931 (1997). 2. Stefan, S. et al. Journal of Biological Chemistry. 272:13467-13470 (1997).
Additional info: Recognizes human CaMKII. Species crossreactivity: mouse and rat.

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