Home  >  Products  >  Cancer Antigen 125 (CA125, CA-125, Mucin 16, Mucin-16, MUC16, MUC-16, Ovarian Cancer-related Tumor Marker CA125, Ovarian Carcinoma Antigen CA125)
Cancer Antigen 125 (CA125, CA-125, Mucin 16, Mucin-16, MUC16, MUC-16, Ovarian Cancer-related Tumor Marker CA125, Ovarian Carcinoma Antigen CA125)

Cancer Antigen 125 (CA125, CA-125, Mucin 16, Mucin-16, MUC16, MUC-16, Ovarian Cancer-related Tumor Marker CA125, Ovarian Carcinoma Antigen CA125)

Cat no: C0050-17A

Supplier: United States Biological
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MUC16/CA125 antigen is a serum marker that is used routinely in gynecologic practice to monitor patients with ovarian cancer. It is a mullerian duct differentiation antigen that is overexpressed in epithelial ovarian cancer cells and secreted into the blood, although its expression is not entirely confined to ovarian cancer. Most biochemical studies have concluded that MUC16/CA125 is a high molecular mass glycoprotein. According to the ISOBM-TD-1 workshop, CA125 contains three antigenic domains: A-domain (Oc125), B-domain (M11), C-Domain (Ov197). The CA-125 antigen is present on a mucin-like glycoprotein of >200kD and is detectable on the apical surface of normal endometrium and endocervix. CA 125, a high-molecular-weight mucin, was first defined in 1981 by the monoclonal antibody OC125. It is a large glycoprotein which is anchored to the epithelium by a transmembrane domain and is released into the extracellular space by enzymatic cleavage. CA 125 is composed of an N-terminal domain, a tandem repeat region, and a short cytoplasmic tail. The N-terminal domain consists of 1637aa, the tandem repeat domain is made up of 40
Catalogue number: C0050-17A
Reactivities: Human
Hosts: Mouse
Applications: Immunohistochemistry
Size: 1ml
Form: Supplied as a liquid in 15mM sodium azide.
P type: Mab
Isotype: IgG1
Purity: Supernatant
Alternative names: Mucin 16, Cell Surface Associated
References: 1.Gabriel M, Obrebowska A and Spaczynski M. Bone marrow involvement in ovarian cancer by immunohistochemical assessment. Ginekol Pol. 70(11):819-823 (1999). 2.Alagoz T, Buller R E, Berman M, et al.. What is a normal CA125 level? Gynecologic Oncology. 53:93-97 (1994). 3.Macri C I and Vasilev S A. Highly elevated CA125 and tubo-ovarian abscess mimicking ovarian carcinoma. Gynecologic and Obstetric Investigation. 37:143-144 (1994). 4.Ohmori T, Okada K, Tabei R, et al.. CA125 producing adenocarcinoma of the seminal vesicle. Pathology International. 4:333-337 (1994). 5.Rodriguez J M. Elevated CA125 levels in association with Ki-1 anaplastic lymphoma. Clinical Oncology. 6:137 (1994). 6.Ye C, Ito K, Komatsu Y, et al.. Extremely high levels of CA19-9 and CA125 antigen in benign mucinous ovarian cystadenoma. Gynecologic Oncology. 52:267-271 (1994). 7.Franchi M, Beretta P, Zanaboni F, et al.. Use of serum CA125 measurement in patients with endometriosis. Italian Journal of Gynaecology and Obstetrics. 5:149-153 (1993).
Additional info: Recognizes Ovarian Cancer Antigen. Species Crossreactivity: Human.

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