CB2 Cannabinoid receptors are present in the immune system and are associated with producing antinociception to external stimuli, such as temperature. Unlike CB(1) receptors, CB(2) receptors are expressed in the periphery, and not the central nervous system. CB2 has been reported in tissues of the immune system, including spleen and tonsil. In blood, CB2 is highest in B-cells > natural killer cells >> monocytes > polymorphonuclear neutrophil cells > T8 cells > T4 cells (Giliegue et al., 1995). ESTs have been isolated from blood, lymph, placenta, and tonsil libraries.
Applications:
Suitable for use in Immunohistochemistry. Other applications not tested.
Recommended Dilution:
Immunohistochemistry (paraffin): 13ug/ml
Optimal dilutions to be determined by the researcher.
Positive Control:
Human Tonsil, Germinal Center and Mantle Zone
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
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