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Cannabinoid Receptor 2 (CNR3, cannabinoid receptor 2 (macrophage), HGNC:2160, CB2, CX5, OTTHUMP00000044841)

Cannabinoid Receptor 2 (CNR3, cannabinoid receptor 2 (macrophage), HGNC:2160, CB2, CX5, OTTHUMP00000044841)

Cat no: C1075-75Q

Supplier: United States Biological
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Cannabinoids exert their well known physiological effects through two G protein coupled receptors, cannabinoid receptor 1 (CB1) and CB2. Both cannabinoid receptors have been shown to inhibit adenylyl cyclase as well as stimulate the mitogen-activated protein kinase, MAPK. CB1 receptors also modulate ion channels through direct G-protein interactions. Delta 9-tetrahydrocannibinol and related ligands likely exert their psychoactive effects by inhibiting presynaptic N- and P / Q type calcium channels. CB2 is thought to function primarily in the immune system although it has been suggested to be present in the central nervous system, including the retina. Applications: Suitable for use in Western Blot and Immunocytochemistry. Other applications not tested. Recommended Dilutions: Western Blot: 1:250. Detects a band at ~60kD from human spinal cord homogenate Immunocytochemistry: 1:100 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C1075-75Q
Reactivities: Human
Hosts: Rabbit
Applications: Immunocytochemistry, Western Blot
Size: 100ul
Form: Supplied as a liquid in PBS, 1mg/ml BSA, 0.05% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
Alternative names: CNR3, cannabinoid receptor 2 (macrophage), HGNC:2160, CB2, CX5, OTTHUMP00000044841
References: 1. Tsou K et al. Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous system. Neuroscience 83:393-411 (1998). 2.Twitchell W et al. Cannabinoids inhibit N- and P/Q-type calcium channels in cultured rat hippocampal neurons. J Neurophysiol 78:43-50 (1997).
Additional info: Recognizes human Cannabinoid Receptor 2.

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