Capsaicin receptor (Vanilloid Receptor 1, VR1)

VR1 (vanilloid receptor 1) is an ion channel activated by capsaicin, the pungent ingredient in hot peppers, and by noxious thermal heat. It is expressed by and isolated from nociceptive sensory neurons. Sequence analysis suggests that VR1 has transmembrane domains and intracellular N- and C-termini. It shares structural similarities with the family of putative store-operated calcium channels. It is thought to function as a transducer of noxious thermal stimuli and have involvement in inflammatory pain.\n\nPeptide Sequence (linear): YTGSLKPEDAEVFKDSMVPGEK\n\nSuitable for use with the following antibodies:\nC1078-10A, C1078-15\n\nApplications: \nSuitable for use in ELISA and Antibody Blocking. Other applications not tested.\n\nStorage and Stability: \nLyophilized powder may be stored at 4 degrees C for short-term only. Stable for 12 months at -20 degrees C. Reconstitute to nominal volume (see reconstitution instructions for peptides) and store at -20 degrees C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.\n\n\n \n

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SPECIFICATIONS

Catalog Number

C1078-02D

Size

1mg

Applications

IHC

Reactivities

Rat

Form

Supplied as a lyophilized powder. Reconstitute with sterile dH2O or PBS.

Purity

Purified ~90%

References

1. Guo, A. Vulchanova, L., Wang, J., Li, X., and Elde, R. Immunocytochemical localization of the vanilloid receptor 1(VR1): relationship to neuropeptides, the P2X3 purinoceptor and IB4 sites. Eur. J. Neuroscience. 11: 946-958, 1999. 2. Caterina, M.J., Schumacher, M.A., Tominaga, M., Rosen, T.A., Levine, J.D. and Julius, D. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature. 389: 816-824, 1997.