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Carabin, CT (FLJ00332, MGC46488, TBC1 Domain Family Member 10C, TBC1D10C)

Carabin, CT (FLJ00332, MGC46488, TBC1 Domain Family Member 10C, TBC1D10C)

Cat no: C1079-15A

Supplier: United States Biological
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Carabin differs from other members of the TBC1 domain protein family, which appear to play a role in the regulation of cell growth and differentiation. Studies demonstrate that Carabin is part of a negative regulatory loop for the intracellular TCR signalling pathway and acts as an inhibitor of the Ras signalling pathway. Carabin is also believed to mediate crosstalk between calcineurin and Ras. Carabin is most abundantly expressed in spleen and peripheral blood leukocytes. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1-2ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C1079-15A
Reactivities: Human, Mouse
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS, 0.02% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Pan, F., et al. (2007) Feedback inhibition of calcineurin and ras by a dual inhibitory protein carabin. Nature; 445:433
Additional info: Recognizes human CARABIN (C-TERMINAL). Species Crossreactivity: mouse.

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