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Carbamazepine

Carbamazepine

Cat no: C-105


Supplier: Alomone Labs Ltd.
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Carbamazepine. Neuronal Nav Channel Inhibitor.

Voltage-gated sodium channels (VGSC, Nav) play a critical role in excitability of nociceptors (pain-sensing neurons). The peripheral-specific sodium channels Nav1.7, Nav1.8 and Nav1.9 are particularly important in the pathophysiology of different pain syndromes and hence, thought to be potential targets for pain therapeutics.
Carbamazepine is a potent and state dependent inhibitor of neuronal Nav channels. It is one of the most commonly prescribed antiepileptic drugs and has long been established as a treatment for neuropathic pain. High doses of carbamazepine are effective in ameliorating symptoms of patients with paroxysmal extreme pain disorder (PEPD) because this disorder involves changes in Nav inactivation, a process that is modulated by Nav blockers. In a recent investigation patients with inherited erythromelalgia, characterized by a mutation in Nav1.7 (SCN9A) and a modified fast inactivation of Na+ current is present, reported an improvement of symptoms when treated with Carbamazepine.
In addition, clinical data also suggest that Carbamazepine can reduce aura and migraine attacks.
Ion Channel Modulators; Voltage-Gated Na+ Channel Blockers.
Catalogue number: C-105
Size: 5 gr
Concentration: IC50 ~ 1 mM
Molecular weight: 236.3 da
Purity: >98%
Shipping temp: Room Temperature
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