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Carbonyl Reductase 4, aa1-237, Recombinant, Human (CBR4, hCBR4, Carbonyl reductase (NADPH) 4)

Cat no: C1146-03B


Supplier: United States Biological
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CBR4 belongs to the short-chain dehydrogenase/reductase family. The formation of heteroteramer with HSD17B8 has NADH-dependent 3-ketoacyl-acyl carrier protein reductase activity for o- and p-quinones. It plays a role in biosynthesis of fatty acids in mitochondria and has broad substrate specificity and reduces 9,10-phenanthrenequinone, 1,4-benzoquinone and various other o-quinones and p-quinones (in vitro). Source: Recombinant corresponding to aa1-237 of human recombinant CBR4 protein, fused to His-tag at N-terminus, expressed in E.coli. AA Sequence: MGSSHHHHHH SSGLVPRGSH MDKVCAVFGG SRGIGRAVAQ LMARKGYRLA VIARNLEGAK AAAGDLGGDH LAFSCDVAKE HDVQNTFEEM EKHLGRVNFL VNAAGINRDG LLVRTKTEDM VSQLHTNLLG SMLTCKAAMR TMIQQQGGSI VNVGSIVGLK GNSGQSVYSA SKGGLVGFSR ALAKEVARKK IRVNVVAPGF VHTDMTKDLK EEHLKKNIPL GRFGETIEVA HAVVFLLESP YITGHVLVVD GGLQLIL Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C1146-03B
Size: 50ug
Form: Supplied as a liquid in 20mM Tris-HCl, pH 8.0, 10% glycerol, 5mM DTT, 200mM sodium chloride.
Purity: ~95% (SDS-PAGE)
References: 1. Endo S., et al. (2008) Biochem Biophys Res Commun. 26;377(4):1326-30. 2. Chen Z., et al. (2009) FASEB J. 23:3682-3691.

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