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Carboxyl Terminal Modulator Protein (CTMP, Thioesterase Superfamily Member 4, THEM4)

Cat no: C1150-01B

Carboxyl Terminal Modulator Protein (CTMP, Thioesterase Superfamily Member 4, THEM4)

Protein kinase B (PKB) is a major downstream target of receptor tyrosine kinases that signal via phosphatidylinositol 3-kinase (PIK3). Upon cell stimulation, PKB is translocated to the plasma membrane, where it is phosphorylated on Thr308 in the catalytic domain and Ser473 in the C-terminal regulatory domain. Several protein partners for PKB have been identified. CTMP, a carboxyl terminal modulator protein, binds to PKB-a and negatively regulates PKB activity by inhibiting phosphorylation of these PKB residues. CTMP (mouse 248aa, human 240aa, chromosome 1q21, 22-26kD) predominantly expressed in skeletal muscle, testis, uterus, brain, and kidney, with lower levels in heart, liver, and lung. The presence of multiple transcripts suggested that CTMP undergoes alternative splicing.\n\nApplications: \nSuitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot: 1-2ug/ml\nImmunohistochemistry (Formalin-fixed paraffin sections): 5ug/ml \nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

C1150-01B

Size

50ug

Applications

ELISA, IHC, WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS, 0.02% sodium azide.\n

P Type

Pab

Purity

Purified by immunoaffinity chromatography.\n\n

Additional Info

Recognizes human THEM4. Species sequence homology: Mouse, rat.

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