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Carcinoembryonic Antigen (CEA)

Carcinoembryonic Antigen (CEA)

Cat no: C1300-01G

Supplier: United States Biological
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Carcinoembryonic Antigen (CEA) is synthesized during development in the fetal gut, and is re-expressed in increased amounts in intestinal carcinomas and several other tumors. Antibodies to CEA are useful in identifying the origin of various metastatic adenocarcinomas and in distinguishing pulmonary adenocarcinomas (60 to 70% are CEA+) from pleural mesotheliomas (rarely or weakly CEA+). Applications: Suitable for use in ELISA and Immunohistochemistry. Other applications not tested. Recommended Dilutions: ELISA: No reaction is observed with normal human plasma stripped of CEA in double antibody sandwich ELISA. Immunohistochemistry (Paraffin): 1:75-1:200. Enzymatic antigen retrieval is recommended. Optimal dilutions to be determined by the researcher.e Positive Control: Hepatic metastasis of colon adenocarcinoma Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C1300-01G
Reactivities: Human
Hosts: Rabbit
Applications: ELISA, Immunohistochemistry
Size: 1ml
Form: Supplied as a liquid in 0.1M sodium chloride, pH 7.2, 15mM sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified
References: This product has been used in:Nap M et al. Cross-reactivity with normal antigens in commercial anti-CEA sera, used for immunohistology. The need for tissue controls and absorptions. Am J Clin Pathol 79:25-31 (1983). Alkushi A et al. Immunoprofile of cervical and endometrial adenocarcinomas using a tissue microarray. Virchows Arch 442:271-7 (2003). Morrison C et al. A comparison of CD10 to pCEA, MOC-31, and hepatocyte for the distinction of malignant tumors in the liver. Mod Pathol 15:1279-87 (2002). Beauchemin N et al. Redefined nomenclature for members of the carcinoembryonic antigen family. Exp Cell Res 252:243-9 (1999). Shield PW et al. Immunocytochemical staining of cytologic specimens. How helpful is it? Am J Clin Pathol 105:157-62 (1996). Sanders DS et al. Classification of CEA-related positivity in primary and metastatic malignant melanoma. J Pathol 172:343-8 (1994). Sheahan K et al. Differential reactivities of carcinoembryonic antigen (CEA) and CEA-related monoclonal and polyclonal antibodies in common epithelial malignancies. Am J Clin Pathol 94:157-64 (1990).
Additional info: Recognizes the human Carcinoembryonic Antigen (CEA). Reacts with CEA like proteins, for example, CEACAM1 and CEACAM6.

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