Home  >  Products  >  Carcinoembryonic Antigen (CEA, Carcinoembryonic Antigen-related Cell Adhesion Molecule 5, CEACAM5, CD66e, CD66e Antigen, DKFZp781M2392, Meconium Antigen 100)
Carcinoembryonic Antigen (CEA, Carcinoembryonic Antigen-related Cell Adhesion Molecule 5, CEACAM5, CD66e, CD66e Antigen, DKFZp781M2392, Meconium Antigen 100)

Carcinoembryonic Antigen (CEA, Carcinoembryonic Antigen-related Cell Adhesion Molecule 5, CEACAM5, CD66e, CD66e Antigen, DKFZp781M2392, Meconium Antigen 100)

Cat no: C1299-92B

Supplier: United States Biological
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Human carcinoembryonic antigen (CEA) belongs to a family of membrane glycoproteins that are overexpressed in many carcinomas. It functions in vitro as a homotypic intercellular adhesion molecule and can inhibit differentiation when expressed ectopically in myoblasts. It was originally described as a glycoprotein molecule with an oncofetal expression pattern. It is a member of a family of closely related molecules, whose genes reveal a high degree of sequence similarity. The CEA family shows structural resemblance to, and can be placed within, the immunoglobulin superfamily. CEA may function as a cell adhesion molecule, which could play an important role during embryogenesis and possibly also during tumor development. Despite its presence in some normal tissues, its concentration in serum is a clinically useful parameter, especially in the postoperative monitoring of colonic tumor patients. It maps to 19q13.1-q13.2 region of human chromosome. It is found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon. Applications: Suitable for use in Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:50-1:100 Immunohistochemistry (formalin fixed paraffin embedded): 1:25-1:80 Immunoprecipitation: 1:50 Optimal dilutions to be determined by the researcher. Positive Control: Colan Carcinoma Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C1299-92B
Reactivities: Human
Hosts: Mouse
Applications: Immunohistochemistry, Immunoprecipitation, Western Blot
Size: 500ul
Form: Supplied as a liquid, 0.05% sodium azide.
P type: Mab
Isotype: IgG2a
Purity: Ascites
References: 1. Albers et al. Am J Pathol 90: 17, 1988. 2. Ellis et al. J Clin Pathol 41: 1064, 1988. 3. Oikawa et al. Biochem Biophys Res Commun 144: 634, 1987. 4. Pfaltz et al. Virchows Arch A 411: 387, 1987. 5. Gold et al. J Exp Med 121: 439, 1965. 6. Schrewe et al. Mol Cell Biol 10: 2738, 1990. 7. Benchimol et al. Cell 57: 327, 1989.
Additional info: Recognizes human CEA.

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