Carcinoembryonic antigen-related cell adhesion molecule 5. Human carcinoembryonic antigen (CEA) belongs to a family of membrane glycoproteins that are overexpressed in many carcinomas. It functions in vitro as a homotypic intercellular adhesion molecule and can inhibit differentiation when expressed ectopically in myoblasts. It was originally described as a glycoprotein molecule with an oncofetal expression pattern. It is a member of a family of closely related molecules, whose genes reveal a high degree of sequence similarity. The CEA family shows structural resemblance to, and can be placed within, the immunoglobulin superfamily. It may function as a cell adhesion molecule, which could play an important role during embryogenesis and possibly also during tumor development. Despite its presence in some normal tissues, its concentration in serum is a clinically useful parameter, especially in the postoperative monitoring of colonic tumor patients. It maps to 19q13.1-q13.2 region of human chromosome. It is found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon.
Applications:
Suitable for use in Immunohistochemistry Other applications not tested.
Recommended Dilution:
Immunohistochemistry (formalin fixed paraffin embedded): 1:75-1:200
Optimal dilutions to be determined by the researcher.
Positive Control:
Colon carcinoma
Storage and Stability:
May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
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