Carcinoembryonic Antigen, Recombinant, Human, 90+% (CEA, CD66e)

Recombinant Human Carcinoembryonic Antigen is glycosylated with N-linked sugars and produced using baculovirus vectors in insect cells. rHuCEA is a well known tumor marker corresponding to the full length human CEA which is approximately 120kD.\n\nDimers and Aggregates:\n(same/less than) 1% as determined by silver-stained SDS-PAGE gel analysis.\n\nStorage and Stability:\nFor long-term storage, add 0.1% HSA or BSA, aliqot and store at -20 degrees C. Aliquots are stable for at least 6 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

C1300-08F

Size

2ug

Form

Supplied as a liquid in 10mM sodium phosphate, pH 7.0, 150mM sodium chloride.

Purity

(same/more than) 90% by RP-HPLC, FPLC, or reducing/non-reducing SDS-PAGE Silver Stain; Purified by proprietary chromatographic techniques. Endotoxin: (same/less than) 0.1ng/ug (IEU/ug) of Human CEA.

References

US Biological application reference: Nicol, G.R. et al., (2008) Molecular & Cellular Proteomics 7:1974-1982. 1. Cloning and sequencing of variable region cDNAs of a novel human monoclonal antibody to carcinoembryonic antigen, and generation of a single chain variable fragmented antibody. Shibaguchi H, Kuroki M, Badran A, Anticancer Res 2004 Sep-Oct;24(5C):3355-60 2. Serum carcinoembryonic antigen levels in patients operated for colorectal carcinoma. Veingerl B, Wien Klin Wochenschr 2001;113 Suppl 3:32-8 3. Tuech et al.: Detection of occult liver metastases in colorectal cancer by measurement of biliary carcinoembryonic antigen concentration: a prospective study. Fielding LP, J Surg Oncol 2004 Nov 1;88(2):108 4. Detection of occult liver metastases in colorectal cancer by measurement of biliary carcinoembryonic antigen concentration: a prospective study. Tuech JJ, Pessaux P, Daver A, J Surg Oncol 2004 Oct 1;88(1):27-31 5. Clinical significance of serum carcinoembryonic antigen, carbohydrate antigen 19-9, and squamous cell carcinoma antigen levels in esophageal cancer patients. Kosug i S, Nishimaki T, Nakagawa S, World J Surg 2004 Jul;28(7):680-5 6. Augmentation of antitumor activity of a recombinant adeno-associated virus carcinoembryonic antigen vaccine with plasmid adjuvant. Ponnazhagan S, Mahendra G, Aldrich WA, Kallman L, Hum Gene Ther 2004 Sep;15(9):856-64.