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CARD4 (Nucleotide-binding Oligomerization Domain-containing Protein 1, Caspase Recruitment Domain-containing Protein 4, NOD1)

CARD4 (Nucleotide-binding Oligomerization Domain-containing Protein 1, Caspase Recruitment Domain-containing Protein 4, NOD1)

Cat no: C1340-01E

Supplier: United States Biological
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Nod1 is implicated in the intracellular detection of pathogen associated molecule, such as, microbial peptidoglycans and signals the activation of NF-kB. Nod1 has an NH2-terminal CARD-linked to a nucleotide-binding domain and a COOH-terminal segment with multiple leucine-rich repeats, which are involved in binding to multiple caspases with long prodomains, but specifically activated caspase-9 and promoted caspase-9-induced apoptosis. Nod1 is a leucine-rich repeat-containing Apaf-1-like molecule that can regulate both apoptosis and NF-kB activation pathways. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:1000-1:2500 Optimal dilutions to be determined by the researcher. Positive Control: Recombinant fusion protein Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C1340-01E
Reactivities: Human
Hosts: Rabbit
Applications: Western Blot
Size: 100ul
Form: Supplied as a liquid, 0.025% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Serum
References: 1. Inohara N, Koseki T, del Peso L, Hu Y, Yee C, Chen S, Carrio R, Merino J, Liu D, Ni J, Nunez G. J Biol Chem. 274 (21):14560-14567 (1999). 2. Girardin SE, Travassos LH, Herve M, Blanot D, Boneca IG, Philpott DJ, Sansonetti PJ, Mengin-Lecreulx D. J Biol Chem. 278(43):41702-8 (2003). Epub 2003 Jul 18. 3. Kim JG, Lee SJ, Kagnoff MF. Infect Immun. 72(3):1487-1495 (2004).
Additional info: Recognizes human CARD4. Species sequence homology: mouse and monkey.

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