CARD9 (Blocking Peptide) (Caspase Recruitment Domain)

Apoptosis is related to many diseases and development. Cell death signals are transduced by death domain (DD), death effector domain (DED), and caspase recruitment domain (CARD) containing molecules. CARD containing proteins include some caspases, Apaf-1, CARD4, IAPs, RICK, ARC, RAIDD, Bcl-10, and ASC. A novel CARD containing protein was recently identified and designated CARD9, which interacts with the CARD activation domain of Bcl-10 (1). CARD9 associates with Bcl-10 and forms a complex within cells. CARD9 induces apoptosis and activates NF-kB. CARD9 is an upstream activator of Bcl-10 and NF-kB signaling.\n\nSynthetic peptide (DRENTTGSDNTDTEGS) corresponding to amino acids 521 to 536 of human CARD9 (1). The sequence is different from that of rat origin by two amino acids (1).

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SPECIFICATIONS

Catalog Number

C1350P

Size

50ug

Form

Supplied as a liquid at 200ug/ml in PBS, pH7.2 (10mM sodium phosphate monobasic, 10mM sodium phosphate dibasic, 130mM sodium chloride), 0.1% bovine serum albumin, 0.02% sodium azide.

References

1. Bertin J, Guo Y, Wang L, Srinivasula SM, Jacobson MD, Poyet JL, Merriam S, Du MQ, Dyer MJ, Robison KE, DiStefano PS, Alnemri ES. CARD9 is a novel caspase recruitment domain-containing protein that interacts with BCL10/CLAP and activates NF-kappa B. J Biol Chem.:275(52):41082

Additional Info

Detection of CARD9. A band at approximately 59kD can be detected.