Home  >  Products  >  CARM1 (Coactivator-Associated Arginine Methyltransferase 1, CARM-1, Histone-arginine Methyltransferase CARM1, Protein Arginine N-methyltransferase 4, PRMT4)
CARM1 (Coactivator-Associated Arginine Methyltransferase 1, CARM-1, Histone-arginine Methyltransferase CARM1, Protein Arginine N-methyltransferase 4, PRMT4)

CARM1 (Coactivator-Associated Arginine Methyltransferase 1, CARM-1, Histone-arginine Methyltransferase CARM1, Protein Arginine N-methyltransferase 4, PRMT4)

Cat no: C1386-31N

Supplier: United States Biological
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CARM1 identified as a SRC-2/TIF2/GRIP1-binding protein, belongs to a family of arginine-specific protein methyltransferases, which includes at least seven members. CARM1 has been shown to synergistically stimulate transcription by nuclear receptors in combination with the p160 family of coactivators and forms a ternary complex with p300/CBP and SRC-2/TIF2/GRIP1. Recent studies broadened the targets of the transcriptional coactivator function of CARM1: CARM1 coactivates p53-dependent transcription and cooperates with -catenin to enhance transcriptional activation by the lymphoid enhancer factor/T-cell factor (LEF1/TCF4). The protein is also a novel transcriptional coactivator of NF- B and functions as a promoter-specific regulator of NF- B recruitment to chromatin. CARM1 also promotes adipocyte differentiation by coactivating PPARgamma-mediated transcription and thus might be important in energy balance. human CARM1 gene is localized on chromosomal region 19p13.2. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:500-1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C1386-31N
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Western Blot
Size: 100ug
Form: Supplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.4, 150mM sodium chloride, 0.02% sodium azide, 50% glycerol.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
Alternative names: EC=2.1.1.-, EC=2.1.1.125
References: 1. Yadav, N. et al. EMBO. Rep. 9:193-198 (2008). 2. Marcela, C. et al. The EMBO Journal. 24:85
Additional info: Recognizes human CARM1.

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