Home  >  Products  >  CARMA2 (Caspase Recruitment Domain-containing Protein 14, CARD-containing MAGUK Protein 2, Carma 2, CARD14)
CARMA2 (Caspase Recruitment Domain-containing Protein 14, CARD-containing MAGUK Protein 2, Carma 2, CARD14)

CARMA2 (Caspase Recruitment Domain-containing Protein 14, CARD-containing MAGUK Protein 2, Carma 2, CARD14)

Cat no: C1350-41A

Supplier: United States Biological
Star_fadedStar_fadedStar_fadedStar_fadedStar_faded
0 reviews | Write a Review Pencil
Read More on Supplier Website
CARMA proteins are scaffold molecules that belong to the membrane-associated guanylate kinase-like (MAGUK) and the caspase-associated recruitment domain (CARD) protein families. They play critical role in antigen receptor signaling pathways. CARMA1, CARMA2, and CARMA3 share homologous sequence and function but are found in different tissues. CARMA1 is predominantly located in lymphoid tissue. CARMA1 protein associates with lipid rafts and interacts with Bcl10, that is required for activation of TCR induced NFkB signaling pathway. Specifically, CARMA1 N-terminal CARD domain binds to Bcl10 CARD motif. It is also essential for protein- induced IL-2 and INF-g production. CARMA genes deactivation studies in mice resulted in reduced immunoglobulin levels and absence of TCR-induced NFkB activation. This suggests that CARMA mutations may lead to adaptive and innate immunity malfunction. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 0.5-2ug/ml Immunohistochemistry: 2.5-20ug/ml (10ug/ml-optimal) Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C1350-41A
Reactivities: Human
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, pH 7.4, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Gaide, O et al. (2002) Nature Immunology 3: 836-843. 2. Hara, H. et al. (2004) JEM, 200(9): 1167-1177. 3. Narayan, P. et al. (2006) Mol Cell Bio 26(6): 2327-2336. 4. Egawa T. et al. (2003) Current Biology 13: 1252-1258. 5. Grabiner, B. et al. (2007) Genes and Dev. 21: 984-996. 6. Newton, K. et al. (2003) Current Biology 13: 1247-1251. 7. Stilo R. et al. (2004) J. Biol. Chem. 279: 34323-34331.
Additional info: Recognizes human CARMA2. Species sequence homology: monkey and chimpanzee.

Get Quote

  • Best Price Guaranteed
  • Quick Response Time
  • Exclusive Promotions
Enquiry_down_arrow
United States Biological
Get a Quote Direct from
United States Biological

By submitting this form you agree to your details being passed to United States Biological for the purpose of generating the best quote*
See Full Product Listings >
Button_on Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave Button_off_biosave