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CARMA2 (Caspase Recruitment Domain-containing Protein 14, CARD-containing MAGUK Protein 2, Carma 2, CARD14)

CARMA2 (Caspase Recruitment Domain-containing Protein 14, CARD-containing MAGUK Protein 2, Carma 2, CARD14)

Cat no: C1350-41B

Supplier: United States Biological
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CARMA proteins are scaffold molecules that belong to the membrane-associated guanylate kinase-like (MAGUK) and the caspase-associated recruitment domain (CARD) protein families. They play critical role in antigen receptor signaling pathways. CARMA1, CARMA2, and CARMA3 share homologous sequence and function but are found in different tissues. Thus, CARMA2 is mostly found in placenta. CARMA2 protein induces NFkB activation; however, signaling pathway it is not yet known. CARMA genes deactivation studies in mice resulted in reduced immunoglobulin levels and absence of TCR- induced NFkB activation. Later suggests that CARMA mutations may lead to adaptive and innate immunity malfunction. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 0.5-2ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: C1350-41B
Reactivities: Mouse
Hosts: Rabbit
Applications: Western Blot
Size: 50ug
Form: Supplied as a liquid in PBS, pH 7.4, 0.05% sodium azide.
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
References: 1. Gaide, O et al. (2002) Nature Immunology 3: 836-843. 2. Hara, H. et al. (2004) JEM, 200(9): 1167-1177. 3. Narayan, P. et al. (2006) Mol Cell Bio 26(6): 2327-2336. 4. Egawa T. et al. (2003) Current Biology 13: 1252-1258. 5. Newton, K. et al. (2003) Current Biology 13: 1247-1251. 6. Grabiner, B. et al. (2007) Genes and Dev. 21: 984-996. 7. Stilo R. et al. (2004) J. Biol. Chem. 279: 34323-34331.
Additional info: Recognizes mouse CARMA2.

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