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CAS Polyclonal Antibody

Cat no: ABP50845

CAS Polyclonal Antibody

Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by CSE1L binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein(chromosome segregation 1 like)may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for CSE1L.

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SPECIFICATIONS

Catalog Number

ABP50845

Size

30micro l, 100micro l, 200micro l

Applications

ELISA, IF, IHC-F, IP, WB

Hosts

Rabbit

Reactivities

Hum

Gene Id

1434

Isotype

Rabbit IgG

Accession

P55060

Clonality

Polyclonal

Concentration

1 mg/ml

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