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CASK (Calmodulin sensitive kinase)

CASK (Calmodulin sensitive kinase)

Cat no: C1035-24A

Supplier: United States Biological
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Calmodulin sensitive kinase (CASK/mLIN-2) is a ~112kD member of the membrane associated quanylate kinase (MAGUK) protein family with multiple protein binding domains. These include an N-terminal calmodulin kinase (CaMKII) domain and C-terminal PDZ, SH3-, and quanylate kinase domains. CASK possesses both tyrosine kinase and serine/threonine kinase activity. In addition, CASK can form a heterotrimeric complex with Mint (X11or mLIN-10) and Veli (mLIN-7) proteins which is predicted to participate in plasma membrane receptor localization. CASK is localized to neuronal synapses and also interacts with syndecan and neurexin. The guanylate kinase domain of CASK has been shown to interact with the T-box transcription factor, Tbr-1, as a coactivator to induce transcription of genes that contain T-elements. Cellular Localization: Cytoplasmic (Potential). Positive Control: Western Blot: AtT20 cell lysate; IHC: mouse brain Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C1035-24A
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug
Form: PBS, 1 mg/ml BSA, 0.05% sodium azide
P type: Pab
Isotype: IgG
Purity: Purified by immunoaffinity chromatography.
Alternative names: Calmodulin sensitive kinase
References: Martinez-Estrada OM et al. Association of junctional adhesion molecule with calcium/calmodulin-dependent serine protein kinase (CASK/LIN-2) in human epithelial caco-2 cells. J Biol Chem 276:9291-6 (2001). Hata Y et al. Synaptic PDZ domain-containing proteins. Neurosci Res 32:1-7 (1998).
Additional info: By Western blot, this antibody detects a 112kD protein representing CASK from AtT20 cell lysate. Immunohistochemical staining of CASK in mouse brain with this antibody results in staining of the choroid plexus. Species Crossreactivity: Crossreacts with Human, Rat and Mouse.

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