CASP12 (Caspase-12, CASP-12, Caspase 12)

Cat no: C2088-58P

Supplier: United States Biological

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Caspase-12 is located in the endoplasmic reticulum (ER). A non-caspase protease, calpain, upon activation by elevated intracellular calcium, may be responsible for the activation and cleavage of caspase-12. Caspase-12 is shown to participate in the development of apoptosis induced by ER-stress. Applications: Suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1-2ug/ml dilution buffer for each mini-gel Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Catalogue number:	C2088-58P
Reactivities:	Mouse
Hosts:	Rat
Applications:	ELISA, Immunohistochemistry, Immunoprecipitation, Western Blot
Size:	25ug
Form:	Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
P type:	Mab
Isotype:	IgG2a
Purity:	Purified by immunoaffinity chromatography.
References:	1. Nakagawa T et al. 2000. J Cell Biol 150:887. 2. Nakagawa T et al. 2000. Nature 403:98. 3. Martinon F et al. 2007. Cell Death and Differentiation 14:10.
Additional info:	Recognizes mouse Caspase-12.

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CASP12 (Caspase-12, CASP-12, Caspase 12)

Cat no: C2088-58P

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