Caspase-1 (mouse) Matched Pair Detection Set (Interleukin-1beta Convertase, IL-1BC, Interleukin-1beta-converting Enzyme, ICE)

Cat no: 044631

Supplier: United States Biological

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Caspase-1 is the best-described inflammatory caspase. It processes the cytokines interleukin-1beta (IL-1beta) and interleukin-18 (IL-18) and induces pyroptotic cell death. Caspase-1 is activated by multiprotein complexes called inflammasomes in response to numerous stimuli that are detected through distinct inflammasomes. NLRC4 responds to cytosolic flagellin, murine NLRP1b responds to anthrax lethal toxin, AIM2 responds to cytosolic DNA and NLRP3/NALP3 responds to a variety of agonists including crystals. The Caspase-1 (mouse) Matched Pair Detection Set contains all reagents for the development of a sandwich ELISA to measure Caspase-1 (mouse) in cell culture supernatants. This Matched Pair Detection Set is a quantitative alternative to Western blotting to measure inflammasome activation leading to Caspase-1 cleavage and secretion. Storage and Stability: Short-term Storage: -20 degrees C Long-term Storage: -20 degrees C

Catalogue number:	044631
Size:	1 Set
Alternative names:	Interleukin-1beta Convertase, IL-1BC, Interleukin-1beta-converting Enzyme, ICE
Additional info:	Detects mouse Caspase-1 (p10 and p20 domain). Does not detect human Caspase-1.

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Caspase-1 (mouse) Matched Pair Detection Set (Interleukin-1beta Convertase, IL-1BC, Interleukin-1beta-converting Enzyme, ICE)

Cat no: 044631

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