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Caspase-1 Polyclonal Antibody

Caspase-1 Polyclonal Antibody

Cat no: ABP57468

Supplier: Abbkine Scientific Co.Ltd.
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CASP1 ?caspase 1)encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. CASP1 was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. CASP1 has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms.
Catalogue number: ABP57468
Reactivities: Human, Rat
Hosts: Rabbit
Applications: ELISA, Immunofluorescence, Immunohistochemistry - fixed, Western Blot
Size: 30micro l, 100micro l, 200micro l
Accession: P29466
Gene: 834
Concentration: 1 mg/ml
Isotype: Rabbit IgG
Clonality: Polyclonal

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