Caspase 10 belongs to the peptidase C14A family. It is involved in the caspase activation cascade and is responsible for the execution of apoptosis. Caspase 10 is recruited to both Fas- and TNFR-1 receptors in a FADD-dependent manner. Caspase 10 may participate in the granzyme B apoptotic pathways. It cleaves and activates caspase-3, -4, -6, -7, -8, and -9. Four isoforms of caspase 10 (caspase 10a, 10b, 10c, and 10d) having the same prodomain but different mature large and small subdomains have been described to date.
Applications:
Suitable for use in ELISA and Western Blot. Other applications not tested.
Recommended Dilution:
ELISA: 0.05-0.2ug/ml
Western Blot: 0.5-1ug/ml
Optimal dilutions to be determined by the researcher.
Storage and Stability:
Lyophilized powder may be stored at -20 degrees C. Reconstitute with sterile 40-50% glycerol, aliquot and store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
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