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Caspase 11 (Casp4, Caspase 4, Aoptosis-related cysteine peptidase, Casp11, ASP-4, Caspase-4, Caspl, Ich3, ich-3, Protease ICH-3)

Caspase 11 (Casp4, Caspase 4, Aoptosis-related cysteine peptidase, Casp11, ASP-4, Caspase-4, Caspl, Ich3, ich-3, Protease ICH-3)

Cat no: C2088-56H

Supplier: United States Biological
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Caspase-11, (also known as CASP-11, ICH-3, ICE-B) promotes IL-b processing by procaspase-1 (ICE) and therefore may also have a role in inflammatory response as evident by a 30 fold increase in CASP-11 activity by LPS. The mouse and rat CASP-11 (373aa) are most homologous to human CASP-4 (377aa) protein (ICErel-II, TX, ICH-2) and could possibly be the ortholog of human CASP-4. The pro-or zymogen form of CASP-11 is activated by Granzyme-B or cathepsin-B and the processed enzyme consists of two large p20 (20kD) and two small ~p10 (10kDa subunits. CASP-11 is highly expressed in lung and spleen, weaker in heart and very little in liver, kidney, testis and skeletal muscle but has not been detected in the brain. Applications: Suitable for use in Western Blot, Immunoprecipitation and Immunohistochemistry (Fr). Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Catalogue number: C2088-56H
Reactivities: Mouse, Rat
Hosts: Rat
Applications: Immunohistochemistry, Immunoprecipitation, Western Blot
Size: 100ul
Form: 15mM Sodium Azide; 1% BSA, 0.01M PBS. pH 7.4
P type: Mab
Isotype: IgG2a
Purity: Purified by Protein A affinity chromatography.
References: Wang S et al. Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE. Cell 92:501-9 (1998). Thornberry NA & Lazebnik Y Caspases: enemies within. Science 281:1312-6 (1998). Wang S et al. Identification and characterization of Ich-3, a member of the interleukin-1beta converting enzyme (ICE)/Ced-3 family and an upstream regulator of ICE. J Biol Chem 271:20580-7 (1996).
Additional info: Species Crossreactivity: Crossreacts with Mouse.Expected to crossreact with Rat due to sequence homology.Not yet tested in other species.

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